Mesoporous Polydopamine Nanotherapeutics for MRI-Guided Cancer Photothermal and Anti-Inflammatory Therapy
The incorporation of Arg doping into MAGM NPs was intended to boost its photothermal conversion efficiency and reactive oxygen species (ROS) scavenging ability. Additionally, synergizing with the anti-inflammatory agent meloxicam (MX) within the nanoparticles aimed to enhance the anti-inflammatory effect following photothermal therapy. Furthermore, gadolinium ions (Gd<sup>3+</sup>) were chelated into the nanostructure to enable precise T1-T2 dual-mode magnetic resonance imaging (MRI) of the intratumor accumulation profile. This imaging capability was leveraged to guide the implementation of photothermal therapy. Animal experiments demonstrated that MAGM NPs exerted a notable anticancer effect in a 4T1 breast cancer mouse model, under the precise guidance of MRI.
Authors
- Hangzhan Ma
- Xintao Shuai (ORCID: https://orcid.org/0000-0003-4271-0310)
- Zhong Cao (ORCID: https://orcid.org/0000-0003-4004-1037)
- Chunan Wang (ORCID: https://orcid.org/0000-0003-0810-6400)
- Jinming Wang (ORCID: https://orcid.org/0000-0002-2076-3764)
- Sitong Liu (ORCID: https://orcid.org/0000-0001-6699-4579)
- Kai Jiang
- Xu Jiayun
- Ruitao Lü
- Yang Liu (ORCID: https://orcid.org/0000-0002-7240-1546)
Institutions
- Sun Yat-sen University (CN)
- Panyu Hospital of Chinese Medicine (CN)
- Stomatology Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Shenzhen Institute for Drug Control (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.2147/ijn.s467419
- Citations
- 5
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.92