Vascular and nerve biomarkers in thigh skin biopsies differentiate painful from painless diabetic peripheral neuropathy
This study supports our proposal that increased dermal vasculature, and its disproportionate ratio to reduced nociceptors, may help differentiate painful DPN from painless DPN. This disproportion is greater in the distal calf than the proximal thigh skin; hence, neuropathic pain in DPN is length-dependent and first localized to the distal lower limbs, mainly feet.
Authors
- Dinesh Selvarajah (ORCID: https://orcid.org/0000-0001-7426-1105)
- Solomon Tesfaye (ORCID: https://orcid.org/0000-0003-1190-1472)
- Sharon Caunt (ORCID: https://orcid.org/0000-0003-1479-8861)
- Rosario Privitera
- Pallai Shillo (ORCID: https://orcid.org/0000-0002-4576-3365)
- Praveen Anand (ORCID: https://orcid.org/0000-0002-2478-7042)
- Gordon Sloan (ORCID: https://orcid.org/0000-0001-6164-2662)
- Philippe Donatien
Institutions
- Hammersmith Hospital (GB)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Imperial College London (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- Frontiers in Pain Research
- Published
- 2024-10-25
- DOI
- https://doi.org/10.3389/fpain.2024.1485420
- Citations
- 3
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.98