Single-cell RNA sequencing uncovers molecular mechanisms of intravenous immunoglobulin plus methylprednisolone in Kawasaki disease: attenuated monocyte-driven inflammation and improved NK cell cytotoxicity
The combination of IVIG with methylprednisolone attenuated monocyte-driven inflammation and improved NK cell cytotoxicity which might provide clues for pediatricians to consider treatment options for children with KD. Whether the monocyte-driven hyperinflammatory state and NK cell function can be indicators for the clinical choice of IVIG with methylprednisolone therapy in KD needs further investigation.
Authors
- Y.-H. Chen (ORCID: https://orcid.org/0000-0001-6590-6338)
- Minna Yang (ORCID: https://orcid.org/0000-0001-6650-9342)
- Hongmao Wang
- Mingming Zhang (ORCID: https://orcid.org/0000-0001-8480-0280)
- Zheng Yang (ORCID: https://orcid.org/0000-0002-7000-0466)
- Chenhui Feng
- Xiaohui Li
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Capital Institute of Pediatrics (CN)
- Children's Hospital of Capital Institute of Pediatrics (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.3389/fimmu.2024.1455925
- Citations
- 8
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 4.58