Daikenchuto, a Japanese herbal medicine, ameliorates experimental colitis in a murine model by inducing secretory leukocyte protease inhibitor and modulating the gut microbiota
These results indicate that DKT exerts anti-inflammatory effects on the intestinal epithelial barrier by SLPI induction, due, at least in part, to increased butyrate-producing bacteria and enhanced butyrate levels in the colon. These results provide insight into the mechanism of the therapeutic effects of DKT on IBD.
Authors
- Nozomi Sachi
- Thanyakorn Chalalai
- Supanuch Ekronarongchai (ORCID: https://orcid.org/0000-0003-2231-2163)
- Takashi Kobayashi (ORCID: https://orcid.org/0000-0002-9069-5736)
- Sotaro Ozaka (ORCID: https://orcid.org/0000-0002-6283-7012)
- Kazunari Murakami (ORCID: https://orcid.org/0000-0003-2668-5039)
- Kazuhiro Mizukami (ORCID: https://orcid.org/0000-0002-3148-8884)
- Shimpei Ariki
- Mitsue Nishiyama (ORCID: https://orcid.org/0000-0002-3878-1290)
- Naganori Kamiyama (ORCID: https://orcid.org/0009-0008-4322-9346)
- Akira Sonoda (ORCID: https://orcid.org/0000-0001-7491-3230)
- Yasuhiro Soga
- Kiyoshi Takeda (ORCID: https://orcid.org/0000-0002-1778-6332)
- Yomei Kagoshima
- Yoko Kudo (ORCID: https://orcid.org/0000-0003-0354-6802)
- Shiori Ishizawa
- Kanako Ito
Institutions
- Oita University (JP)
- Tsumura Research Institute (Japan) (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.3389/fimmu.2024.1457562
- Citations
- 8
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 4.40