Increased thrombin generation in kidney transplant recipients with donor-specific antibodies directed against human leukocyte antigens
In patients with anti-HLA class II DSAs, thrombin generation was significantly increased as compared to DSA- kidney transplant recipients, suggesting that the presence of antibodies is associated with hypercoagulability. Tacrolimus levels were negatively associated with TGA parameters. Hypercoagulability, associated with the presence of DSAs, may potentially contribute to the pathomechanism of antibody-mediated graft injury, warranting future prospective studies.
Authors
- Zsuzsa Bagoly (ORCID: https://orcid.org/0000-0001-5314-5607)
- Zoltán Szalai
- Balázs Nemes (ORCID: https://orcid.org/0000-0002-5942-9587)
- Linda Lóczi
- Anikó Szilvási (ORCID: https://orcid.org/0000-0002-4092-6073)
- Péter Antal‐Szalmás (ORCID: https://orcid.org/0000-0002-9246-726X)
- Rita Orbán-Kálmándi
- Gábor Nagy (ORCID: https://orcid.org/0000-0002-2943-2750)
- Réka P. Szabó (ORCID: https://orcid.org/0000-0002-6289-8085)
- Rebeka Hodossy-Takács
Institutions
- University of Debrecen (HU)
- Hungarian National Blood Transfusion Service (HU)
- Research Network (United States) (US)
- Hungarian Academy of Sciences (HU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.3389/fimmu.2024.1407407
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gedeon Richter
- Hungarian Scientific Research Fund
- Magyar Tudományos Akadémia
- Debreceni Egyetem