Dysregulation of the 3β-hydroxysteroid dehydrogenase type 2 enzyme and steroid hormone biosynthesis in chronic kidney disease
These findings underscore the potential of HSD3B2 as a clinical diagnostic and therapeutic target in CKD. While further studies are warranted to fully elucidate the mechanisms, our results provide valuable insights into the intricate interplay between steroid hormone biosynthesis and CKD. This offers a promising avenue for precision medicine approaches and personalized treatment strategies.
Authors
- Yiyi Zuo (ORCID: https://orcid.org/0009-0007-4503-9362)
- Dongqing Zha
- Jie Jiang (ORCID: https://orcid.org/0000-0001-5228-5915)
- Yang Wan (ORCID: https://orcid.org/0000-0002-5914-3327)
- Yue Zhang (ORCID: https://orcid.org/0000-0001-6349-6849)
- Ziyi Chen (ORCID: https://orcid.org/0009-0005-5847-5011)
- Kangning Wang (ORCID: https://orcid.org/0000-0001-6690-0149)
- Runze Zhang (ORCID: https://orcid.org/0009-0004-9088-7924)
- Qing He (ORCID: https://orcid.org/0009-0003-6395-9374)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.3389/fendo.2024.1358124
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.36
Funders
- National Natural Science Foundation of China
- Wuhan University
- Zhongnan Hospital of Wuhan University