Rational Design of an Activatable Near‐Infrared Fluorogenic Platform for In Vivo Orthotopic Tumor Imaging and Resection
Rational and effective design of a universal near-infrared (NIR) light-absorbed platform employed to prepare diverse activatable NIR fluorogenic probes for in vivo imaging and the imaging-guided tumor resection remains less exploited but highly meaningful. Herein, mandelic acid with a core structure of 4-hydroxylbenzyl alcohol to link recognition unit, a fluorophore and a quencher was employed to prepare activatable probes. We exemplified ester as carboxylesterase (CE)-recognized unit, ferrocene as quencher and phenothiazinium as NIR fluorophore to afford fluorogenic probes termed NBS-Fe-CE and NBS-C-Fe-CE. These probes enabled the conversion toward CE with significant fluorescence increases and successfully discriminate CE activity in cells. NIR light enhances the tumor penetration and enable imaging-guided orthotopic tumor resection. This specific case demonstrated that this platform can be effectively used to construct diverse NIR probes for imaging analytes in biological systems.
Authors
- Gaolin Liang (ORCID: https://orcid.org/0000-0002-6159-9999)
- Juyoung Yoon (ORCID: https://orcid.org/0000-0002-1728-3970)
- Yu Deng (ORCID: https://orcid.org/0000-0002-1909-7223)
- Jingjing Hu (ORCID: https://orcid.org/0000-0002-1449-6137)
- Gyoungmi Kim (ORCID: https://orcid.org/0000-0002-2148-1080)
- Xiaofeng Wu (ORCID: https://orcid.org/0000-0001-5912-4073)
- Jun‐Seok Lee (ORCID: https://orcid.org/0000-0003-3641-1728)
- Rui Wang (ORCID: https://orcid.org/0000-0003-1723-4746)
- Heejeong Kim (ORCID: https://orcid.org/0000-0002-0932-6897)
- Ying Xu (ORCID: https://orcid.org/0000-0002-5471-6739)
- Kyung Tae Hong
Institutions
- Ewha Womans University (KR)
- Korea University (KR)
- China University of Geosciences (CN)
- China University of Geosciences (Beijing) (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
- Korea Institute of Science and Technology (KR)
- Southeast University (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1002/anie.202416877
- Citations
- 17
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 7.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Southeast University
- Education Department of Hainan Province