Systematic identification of therapeutic targets for coronary artery calcification: an integrated transcriptomic and proteomic Mendelian randomization
The integrated MR analysis of transcriptomic and proteomic data identified multiple potential drug targets for the treatment of CAC. ULK3, DOT1L, and AMH were recognized as novel targets for drug repurposing for CAC and deserve further investigation.
Authors
- Xingwu Ran (ORCID: https://orcid.org/0000-0002-6634-1241)
- Xiaoqi Ye (ORCID: https://orcid.org/0000-0002-8703-9551)
- Zhiyong Li (ORCID: https://orcid.org/0000-0002-6814-9165)
- Lihong Chen (ORCID: https://orcid.org/0000-0003-2385-4466)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2024-10-25
- DOI
- https://doi.org/10.3389/fcvm.2024.1419440
- Citations
- 1
- Primary Topic
- Dermatological and Skeletal Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.55