Dexmedetomidine ameliorates acute kidney injury by regulating mitochondrial dynamics via the α2-AR/SIRT1/PGC-1α pathway activation in rats
DEX ameliorated septic AKI by reducing oxidative stress and apoptosis in addition to modulating mitochondrial dynamics via upregulation of the α2-AR/SIRT1/PGC-1α pathway. This is a confirmatory study about DEX pre-treatment to ameliorate septic AKI. Our research reveals a novel mechanistic molecular pathway by which DEX provides nephroprotection.
Authors
- Haoyang Tan
- Xiujing Feng (ORCID: https://orcid.org/0000-0002-8887-3302)
- Qingtao Hou (ORCID: https://orcid.org/0000-0002-4929-6178)
- Xuanpan Ding (ORCID: https://orcid.org/0000-0002-2751-2810)
- Hao Fang (ORCID: https://orcid.org/0000-0002-2879-5146)
- Honggang Fan (ORCID: https://orcid.org/0000-0002-7671-6908)
- Guiyan Yang
- Junfeng Li (ORCID: https://orcid.org/0009-0009-1233-8926)
- Yuan Zhao (ORCID: https://orcid.org/0000-0002-2864-9210)
- Shuai Zhang (ORCID: https://orcid.org/0000-0003-2157-6837)
- Haotian Yang (ORCID: https://orcid.org/0000-0003-4367-1202)
- Xingxing Li (ORCID: https://orcid.org/0000-0001-9264-5575)
- Siyao Li (ORCID: https://orcid.org/0000-0002-3944-6179)
- Xin Cheng (ORCID: https://orcid.org/0000-0002-0983-7750)
- Yuan Ji (ORCID: https://orcid.org/0000-0002-2631-9082)
- Qichao Tang (ORCID: https://orcid.org/0000-0003-4663-5864)
- Xinyi Dou
- Q. An
- Huijie Kang
Institutions
- Chongqing University (CN)
- Northeast Agricultural University (CN)
- Jilin Agricultural Science and Technology University (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1186/s10020-024-00964-y
- Citations
- 12
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 5.60
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China