Moderate Hypothermia Alleviates Sepsis-Associated Acute Lung Injury by Suppressing Ferroptosis Induced by Excessive Inflammation and Oxidative Stress via the Keap1/GSK3β/Nrf2/GPX4 Signaling Pathway
Collectively, we illustrated a novel potential therapeutic mechanism in which moderate hypothermia could alleviate ferroptosis induced by excessive inflammation and oxidative stress via the regulation of Keap1/GSK3β/Nrf2/GPX4 expression, hence ameliorating acute lung injury in sepsis.
Authors
- Jie Xu
- Liangyan Jiang
- Juntao Hu
- Zhanhong Tang (ORCID: https://orcid.org/0000-0002-5782-5826)
- Jie Lai (ORCID: https://orcid.org/0000-0002-9840-6943)
- Liujun Tao
Institutions
- Suizhou Central Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-10-01
- DOI
- https://doi.org/10.2147/jir.s491885
- Citations
- 15
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 3.51
Funders
- National Natural Science Foundation of China