Scalable Copper Sulfide Formulations for Super‐Resolution Optoacoustic Brain Imaging in the Second Near‐Infrared Window
Optoacoustic imaging offers label-free multi-parametric characterization of cerebrovascular morphology and hemodynamics at depths and spatiotemporal resolution unattainable with optical microscopy. Effective imaging depth can greatly be enhanced by employing photons in the second near-infrared (NIR-II) window. However, diminished absorption by hemoglobin along with a lack of suitable contrast agents hinder an efficient application of the technique in this spectral range. Herein, copper sulfide (CuS) micro- and nano-formulations for multi-scale optoacoustic imaging in the NIR-II window are introduced. Dynamic contrast enhancement induced by intravenously administered CuS nanoparticles facilitated visualization of blood perfusion in murine cerebrovascular networks. The individual calcium carbonate microparticles carrying CuS are further shown to generate sufficient responses to enable super-resolution microvascular imaging and blood flow velocity mapping with localization optoacoustic tomography.
Authors
- Ana María López (ORCID: https://orcid.org/0000-0002-8451-0942)
- Anxo Vidal (ORCID: https://orcid.org/0000-0002-0866-4202)
- Sandeep Kumar Kalva (ORCID: https://orcid.org/0000-0003-1034-7246)
- Daniil Nozdriukhin (ORCID: https://orcid.org/0000-0002-5217-1747)
- Çağla Özsoy (ORCID: https://orcid.org/0000-0002-5620-4796)
- Lin Tang (ORCID: https://orcid.org/0009-0008-3399-1134)
- Quanyu Zhou (ORCID: https://orcid.org/0000-0001-7719-4649)
- Xosé Luís Deán‐Ben (ORCID: https://orcid.org/0000-0002-8557-7778)
- Daniel Razansky (ORCID: https://orcid.org/0000-0001-8676-0964)
- Michael Reiss (ORCID: https://orcid.org/0000-0003-3583-3451)
- Shuxin Lyu
Institutions
- Indian Institute of Technology Bombay (IN)
- Shanxi Medical University (CN)
- Universidade de Santiago de Compostela (ES)
- University of Zurich (CH)
- ETH Zurich (CH)
- Institute for Biomedical Engineering (CH)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
Publication Details
- Journal
- Small Methods
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1002/smtd.202400927
- Citations
- 6
- Primary Topic
- Photoacoustic and Ultrasonic Imaging
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Eidgenössische Technische Hochschule Zürich
- Innosuisse - Schweizerische Agentur für Innovationsförderung
- National Institutes of Health