Nesfatin-1 expression and blood plasma concentration in female dogs suffering from cystic endometrial hyperplasia and pyometra and its possible interaction with phoenixin-14
The etiology of CEH and pyometra are not fully known, although we have expanded the level of knowledge with respect to the possible interaction of nesfatin-1 and phoenixin in female dogs' uteri. They interact oppositely. With increasing female body weight, the expression of nesfatin-1 in the uterus and its peripheral blood concentration increased. However, for female dogs affected by CEH and pyometra, a decreased level of phoenixin-14, irrespective of their body condition score is characteristic. This knowledge could be crucial in the development of biomarkers for these conditions, which may lead to earlier recognition.
Authors
- Anna Łukomska (ORCID: https://orcid.org/0000-0001-5046-7416)
- B Wa̧sowska (ORCID: https://orcid.org/0000-0002-5262-5016)
- Piotr Pawlak (ORCID: https://orcid.org/0000-0003-3489-1684)
- Tomasz Nowak (ORCID: https://orcid.org/0000-0002-1820-5202)
- Marek Skrzypski (ORCID: https://orcid.org/0000-0003-4059-1362)
- Tatiana Wojciechowicz (ORCID: https://orcid.org/0000-0002-3651-0972)
- Maria Billert (ORCID: https://orcid.org/0000-0002-2198-6046)
- Karolina Pusiak
Institutions
- Poznan University of Medical Sciences (PL)
- InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences (PL)
- University of Life Sciences in Poznań (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1186/s12917-024-04336-w
- Citations
- 2
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Faculty of Veterinary Medicine and Animal Science, Poznań University of Life Sciences