Synergistic effect of fosfomycin and colistin against KPC-producing Klebsiella pneumoniae: pharmacokinetics-pharmacodynamics combined with transcriptomic approach
FM combined with COL mediated synergistic bactericidal effect by regulating ROS accumulation and inhibiting ribosomal protein transcription, resulting in lower resistance and cytotoxicity.
Authors
- Junpeng Yue
- Qixia Luo (ORCID: https://orcid.org/0000-0002-9643-7914)
- Wei Yu (ORCID: https://orcid.org/0000-0002-1174-596X)
- Yicheng Huang (ORCID: https://orcid.org/0000-0002-4651-562X)
- Jiajie Zhang (ORCID: https://orcid.org/0000-0001-6182-4044)
- Kanghui Zhang (ORCID: https://orcid.org/0000-0003-1628-1647)
- Kaixuan Dong
- Liqian Xu
Institutions
- National Clinical Research (US)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
- First Affiliated Hospital Zhejiang University (CN)
- State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- Zhejiang University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1186/s12866-024-03581-1
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.51
Funders
- Department of Health of Zhejiang Province