A reassessment of spinal cord pathology in severe infantile spinal muscular atrophy
We provide robust quantification of the neuronal deficit found at the end of life in SMA spinal cord. We question long-accepted dogmas of SMA pathogenesis and shed new light on SMA neuropathology out with the ventral horn, which must be considered in future therapeutic design.
Authors
- Thomas O. Crawford (ORCID: https://orcid.org/0000-0003-0916-2797)
- Hazel Allardyce (ORCID: https://orcid.org/0000-0001-6967-4706)
- Simon H. Parson (ORCID: https://orcid.org/0000-0002-8848-8738)
- Ben Lawrence (ORCID: https://orcid.org/0000-0002-4358-4910)
- Charlotte J. Sumner
Institutions
- Johns Hopkins University (US)
- University of Aberdeen (GB)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Neuropathology and Applied Neurobiology
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1111/nan.13013
- Citations
- 4
- Primary Topic
- Neurogenetic and Muscular Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Spinal Muscular Atrophy Foundation
- Johns Hopkins University
- Anatomical Society
- University of Southampton
- University of Aberdeen
- University of Galway
- Brain Tumour Research
- National Institutes of Health
- Medical Research Council