Insights into the Phytochemical Profile and Therapeutical Potential of Withania somnifera (L.) Dunal

<i>Withania somnifera</i> (L.) Dunal (<i>W. somnifera</i>) is an herb commonly known by its English name Winter Cherry, and Ashwagandha in Hindi. It has been used as a traditional Rasayana herb for a long time. It is a rich reservoir of bioactive compounds known as withanolides, namely, withaferin-A and withanolide-D. Its current research covers many aspects of human health, which include anti-stress, anti-tumor, 9immuno-modulatory, hypocholesterolemic, hepatoprotective, hypoglycemic, diuretic, anti-convulsant, neurotropic, adaptogenic, and cardioprotective properties. This overview <i>W. somnifera</i> traditional uses, phytochemical, and pharmacological activities. However, in-depth studies are needed on the clinical use of <i>W. somnifera</i> against human diseases. Besides, detailed toxicological analysis is also to be performed for its safe and efficacious use in preclinical and clinical studies and as a health-promoting herb.