Unraveling the Ferroptosis-inducing Potential of Methanol Leaves Extract of Prosopis Juliflora Via Downregulation of SLC7A11 and GPX4 mRNA Expression in A549 Lung Cancer Cells
The study also found that PJME has the ability to activate ferroptosis pathways, as evidenced by elevated reactive oxygen species (ROS) generation, changes in the levels of antioxidant markers (MDA and GSH), and decreased expression of SLC7A11 and GPX4. The results of the present study clearly showed that PJME inhibited the proliferation of A549 cells and induced ferroptosis by reducing the expression of the important targets SLC7A11 and GPX4. Further research is necessary to fully understand the clinical efficacy of PJME before it can be investigated as supplemental or adjuvant therapy for lung cancer.
Authors
- Hadeel R. Bakhsh (ORCID: https://orcid.org/0000-0002-3000-880X)
- Pratibha Pandey (ORCID: https://orcid.org/0000-0002-3122-4352)
- Safia Obaidur Rab (ORCID: https://orcid.org/0009-0000-2021-4450)
- Nawaf I. Alshammari (ORCID: https://orcid.org/0000-0001-7525-8573)
- Monika Singh (ORCID: https://orcid.org/0000-0002-6667-1160)
- Mοhd Saeed (ORCID: https://orcid.org/0000-0003-3443-386X)
- Alya Redhwan (ORCID: https://orcid.org/0000-0002-0602-6442)
- Fahad Khan (ORCID: https://orcid.org/0000-0003-3449-7978)
- Mohd Asif Shah (ORCID: https://orcid.org/0000-0001-6164-0915)
- Sorabh Lakhanpal (ORCID: https://orcid.org/0000-0001-8375-4702)
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Lovely Professional University (IN)
- Kardan University (AF)
- Uttaranchal University (IN)
- University of Ha'il (SA)
- Chitkara University (IN)
- King Khalid University (SA)
- Saveetha University (IN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2024-10-25
- DOI
- https://doi.org/10.2174/0109298673343133241011072425
- Citations
- 5
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Princess Nourah Bint Abdulrahman University
- King Khalid University