Effects of Ethanol Extract from Senna Leaf (EESL) on Inflammation and Oxidative Stress in Mice: A Non-targeted Metabolomic Study
Senna leaf can inhibit the expression of tight junction proteins in the intestinal mucosa and disrupt intestinal mucosal barrier integrity, exacerbating oxidative stress and inflammation induced by bacterial LPS entering the bloodstream. In addition, the impact of Senna leaf on tryptophan metabolism may be linked to the occurrence of drug dependence.
Authors
- Wen Sun (ORCID: https://orcid.org/0000-0002-8111-8865)
- Jiajun Tan (ORCID: https://orcid.org/0009-0005-6388-2543)
- Xiaoli Huang (ORCID: https://orcid.org/0000-0002-2833-3523)
- Fumeng Yang (ORCID: https://orcid.org/0000-0002-2636-7340)
- Liang Wu (ORCID: https://orcid.org/0009-0003-2377-093X)
- Chang Sun (ORCID: https://orcid.org/0009-0004-2484-7131)
Institutions
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- The First People’s Hospital of Lianyungang (CN)
- Xian Yang Central Hospital (CN)
Publication Details
- Journal
- Endocrine Metabolic & Immune Disorders - Drug Targets
- Published
- 2024-10-25
- DOI
- https://doi.org/10.2174/0118715303325372241014152811
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu University