Establishment of an Integrated Population Pharmacokinetic/ Pharmacodynamics Model of Apixaban in Chinese Healthy Population Adjusting for Key Genetic Variants
We established a comprehensive PK/PD model and used it to simulate markers level such as APTT, PT, and anti-FXa of apixaban. Individual predictive values with a dose of 2.5 mg are basically within the expected recommended range.
Authors
- Maoxing Liao
- Qiufen Xie
- Zhiyan Liu (ORCID: https://orcid.org/0000-0001-9668-7756)
- Jiachun Bao
- Jinfang Song (ORCID: https://orcid.org/0000-0002-1138-6186)
- Guangyan Mu (ORCID: https://orcid.org/0000-0001-6644-9933)
- Qian Xiang (ORCID: https://orcid.org/0000-0002-8245-2611)
- Yimin Cui (ORCID: https://orcid.org/0000-0002-4186-1005)
- Zhe Wang (ORCID: https://orcid.org/0000-0003-2017-1045)
- Kun Hu (ORCID: https://orcid.org/0009-0009-0378-4369)
- Zining Wang (ORCID: https://orcid.org/0000-0002-6691-8258)
- Shuang Zhou (ORCID: https://orcid.org/0000-0003-0761-5094)
- Yaou Liu (ORCID: https://orcid.org/0000-0003-3779-2753)
- Hanxu Zhang (ORCID: https://orcid.org/0000-0002-4113-1643)
- Xianmin Meng (ORCID: https://orcid.org/0000-0002-1747-7783)
- Xia Zhao
Institutions
- Jiangnan University (CN)
- Peking University (CN)
- Tianjin Medical University General Hospital (CN)
- Shanghai Public Health Clinical Center (CN)
- Wuxi Fourth People's Hospital (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2024-10-25
- DOI
- https://doi.org/10.2174/0113816128306062241007053405
- Primary Topic
- Pharmacy and Medical Practices
- Type
- article
- Field-Weighted Citation Impact
- 0.00