Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins
This study demonstrates that layilin contributes to ΔΨm reduction to promote apoptosis by up-regulating BAD and down-regulating BCL-2 in glioma cells. Our data elucidates a new function of layilin: regulation of mitochondria-mediated apoptosis.
Authors
- Atsuhiro Tsutiya (ORCID: https://orcid.org/0000-0002-1004-538X)
- Manae S. Kurokawa (ORCID: https://orcid.org/0000-0001-6503-404X)
- Kazuki Omoteyama
- Naoya Suematsu (ORCID: https://orcid.org/0000-0003-1778-3294)
- Mitsumi Arito (ORCID: https://orcid.org/0000-0002-1238-6612)
- Masaaki Sato (ORCID: https://orcid.org/0000-0003-0564-4318)
- Toshiyuki Sato (ORCID: https://orcid.org/0000-0002-4515-4201)
- Tomohiro Kato
- Yusei Motonaga
Institutions
- St. Marianna University School of Medicine (JP)
Publication Details
- Journal
- BMC Molecular and Cell Biology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1186/s12860-024-00521-9
- Citations
- 9
- Primary Topic
- Toxin Mechanisms and Immunotoxins
- Type
- article
- Field-Weighted Citation Impact
- 2.16
Funders
- Japan Society for the Promotion of Science