Bioactive potential of copper and chromium doped manganese oxide nanoparticles

 Copper and chromium-based nanoparticles are employed in the treatment of various diseases due to their antifungal, antiviral, antibacterial, and antioxidant properties.  Recent research conducted at the University of Okara aimed to evaluate the antibacterial, antifungal, and antioxidant potential of copper and chromium-doped manganese oxide nanoparticles.  The nanoparticles were synthesized using the hydrothermal method. To determine their antibacterial potential, disc diffusion and agar well diffusion methods were utilized. Characterization of the nanoparticles was performed using powder X-ray diffraction, Fourier transform infrared spectroscopy, and energy-dispersive X-ray spectroscopy to confirm their properties. The antibacterial efficacy of the nanoparticles was tested against Klebsiella pneumoniae, E. coli, and Bacillus subtilis  All antibiotics demonstrated antibacterial activity except Trimethoprim and Amoxicillin, while copper-doped manganese  oxide nanoparticles showed no antibacterial potential. Chromium-doped manganese oxide nanoparticles exhibited antibacterial potential at various concentrations. The antifungal potential of copper nanoparticles was tested against Fusarium equiseti and Rhizopus stolonife. No inhibition was observed against the growth of Rhizopus stolonifer. The antioxidant activity test confirmed that copper and chromium oxide nanoparticles, along with ascorbic acid, possess antioxidant properties. Copper oxide nanoparticles exhibited a maximum antioxidant activity of 67% at a concentration of 0.1 mg/2 ml, while ascorbic acid showed 90%. Chromium oxide nanoparticles demonstrated maximal antioxidant activity of 99%, with ascorbic acid at 83%. Copper nanoparticles had less antioxidant activity than ascorbic acid, whereas chromium nanoparticles had higher activity.   In conclusion, both copper and chromium-doped manganese oxide nanoparticles exhibit antibacterial, antifungal, and antioxidant activities against different pathogens.