Cancer specific up-regulated lactate genes associated with immunotherapy resistance in a pan-cancer analysis
Collectively, we defined a pan-cancer up-lactate signature, which is a feature of malignant cells and is associated with ICIs resistance. This reveals a coherent program with prognostic and predictive value that may be therapeutically targeted.
Authors
- Wenchuan Xie
- Yuyan Xu (ORCID: https://orcid.org/0000-0003-3335-1248)
- Mingxin Pan (ORCID: https://orcid.org/0000-0002-9133-3323)
- Jingyuan Pei (ORCID: https://orcid.org/0000-0002-1973-1028)
- Jiachen Xu
- Yaohong Wen
- Xin Zhu (ORCID: https://orcid.org/0000-0002-2773-4229)
- Shuiting Fu (ORCID: https://orcid.org/0000-0003-1253-9559)
- Guoqiang Wang (ORCID: https://orcid.org/0000-0002-3372-8538)
- Chengcheng Li (ORCID: https://orcid.org/0000-0001-5121-8411)
- H. J. Yang (ORCID: https://orcid.org/0009-0004-8274-9863)
- Chunming Wang (ORCID: https://orcid.org/0000-0003-0261-7920)
- Cheng Zhang (ORCID: https://orcid.org/0000-0002-8121-2405)
- Lei Cai (ORCID: https://orcid.org/0000-0003-1658-7996)
- Hongkun Tan
- Shangli Cai
- Mingyang Tang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Burning Rock Biotech (China) (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e39491
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.23