Antimicrobial and anti-endotoxin activity of N-acetylcysteine, calcium hydroxide and their combination against <i>Enterococcus faecalis, Escherichia coli</i> and lipopolysaccharides
The findings of this study showed significant reductions in the microbial load of <i>E. faecalis</i> and <i>E. coli</i> by S3. Notably, there were no statistically significant differences among the treatment groups concerning these microorganisms. However, it was observed that only the combination of NAC and Ca(OH)<sub>2</sub> led to a noteworthy decrease in the quantity of <i>E. coli's</i> LPS after 7-days, demonstrating a statistically significant difference from the other treatment groups. NAC + Ca(OH)<sub>2</sub> combination, applied for a duration of 7-days, proved to be more suitable in reducing the presence of <i>E. faecalis</i>, <i>E. coli</i>, and LPS from <i>E. coli</i> within the context of endodontic infections.
Authors
- Eduardo Bresciani (ORCID: https://orcid.org/0000-0001-9299-8792)
- Carolina Fedel Gagliardi (ORCID: https://orcid.org/0000-0002-9680-0541)
- Cláudio Antônio Talge Carvalho (ORCID: https://orcid.org/0000-0003-0987-5594)
- Renata Marques de Melo (ORCID: https://orcid.org/0000-0003-0752-6294)
- Márcia Carneiro Valera (ORCID: https://orcid.org/0000-0001-7398-6438)
- Rayana Duarte Khoury (ORCID: https://orcid.org/0000-0001-6403-8348)
- Amjad Abu Hasna (ORCID: https://orcid.org/0000-0002-1112-985X)
Institutions
- Universidad Espíritu Santo (EC)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- PeerJ
- Published
- 2024-10-25
- DOI
- https://doi.org/10.7717/peerj.18331
- Citations
- 4
- Primary Topic
- Endodontics and Root Canal Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.97
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo