DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1
Taken together, our results indicate that DOT1L protects podocyte injury via PLCL1-mediated fatty acid metabolism and provides new insights into the therapeutic target of DKD.
Authors
- Yi Xie (ORCID: https://orcid.org/0000-0002-5672-3158)
- Xianan Zheng
- Qiao Zhou (ORCID: https://orcid.org/0000-0003-2666-2283)
- Bingbing Chen (ORCID: https://orcid.org/0000-0001-5995-4464)
- Yaqiong Wang
- Yepeng Hu (ORCID: https://orcid.org/0009-0009-1681-503X)
- Shu Ye
- Yikai Zhang (ORCID: https://orcid.org/0000-0001-9785-8625)
- Shengyao Wang (ORCID: https://orcid.org/0000-0002-2748-483X)
- Tiekun Li
- Bibi Hu
- Zhe Wang (ORCID: https://orcid.org/0000-0002-7573-1583)
- Yan Han (ORCID: https://orcid.org/0000-0002-2881-1601)
- Zhida Chen (ORCID: https://orcid.org/0000-0001-6756-0860)
- Chao Zheng (ORCID: https://orcid.org/0000-0001-9691-3573)
- Tianyue Zhang (ORCID: https://orcid.org/0000-0002-6125-9038)
- Jianmei Niu (ORCID: https://orcid.org/0000-0002-3380-764X)
- Yiming Zhao (ORCID: https://orcid.org/0000-0003-0153-6846)
- Jing Kong (ORCID: https://orcid.org/0000-0002-8048-3289)
Institutions
- Kingmed Diagnostics (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1186/s12964-024-01895-1
- Citations
- 4
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University
- Natural Science Foundation of Zhejiang Province