Lefamulin dosing optimization using population pharmacokinetic and pharmacokinetic/pharmacodynamic assessment in Chinese patients with community-acquired bacterial pneumonia
This study proved that intravenous and oral administrations of lefamulin can reach preclinical PK/PD targets of <i>S. pneumoniae</i> and <i>S. aureus</i>. These findings support the optimal use of lefamulin for the safe and effective treatment of Chinese CABP patients.
Authors
- Xingchen Bian (ORCID: https://orcid.org/0000-0003-2554-5317)
- Qiong Wei (ORCID: https://orcid.org/0000-0001-6836-9929)
- Xiaojie Wu (ORCID: https://orcid.org/0000-0002-0081-6507)
- Jufang Wu (ORCID: https://orcid.org/0000-0001-8619-0690)
- Nanyang Li (ORCID: https://orcid.org/0000-0002-4434-8514)
- Yang Wang (ORCID: https://orcid.org/0000-0002-1723-3869)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-2966-9149)
- Yi Li (ORCID: https://orcid.org/0009-0001-9682-7242)
- Jingjing Wang (ORCID: https://orcid.org/0000-0002-7767-3196)
- Xu Zhu (ORCID: https://orcid.org/0000-0001-9300-4307)
- Yingying Hu (ORCID: https://orcid.org/0000-0002-3179-3977)
- Jicheng Yu
- Haijing Yang
- Guoying Cao (ORCID: https://orcid.org/0000-0002-8321-6637)
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.3389/fphar.2024.1456741
- Citations
- 1
- Primary Topic
- Veterinary medicine and infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.64
Funders
- Fudan University
- Huashan Hospital