Best Practices in Developing a Workflow for Uncertainty Quantification for Modeling the Biodegradation of Mg‐Based Implants

Computational models of electrochemical biodegradation of magnesium (Mg)-based implants are uncertain. To quantify the model uncertainty, iterative evaluations are needed. This presents a challenge, especially for complex, multiscale models as is the case here. Approximating high-cost and complex models with easy-to-evaluate surrogate models can reduce the computational burden. However, the application of this approach to complex degradation models remains limited and understudied. This work provides a workflow to quantify different types of uncertainty within biodegradation models. Three surrogate models-Kriging, polynomial chaos expansion, and polynomial chaos Kriging-are compared based on the minimum number of samples required for surrogate model construction, surrogate model accuracy, and computational time. The surrogate models are tested for three computational models representing Mg-based implant biodegradation. Global sensitivity analysis and uncertainty propagation are used to analyze the uncertainties associated with the different models. The findings indicate that Kriging proves effective for calibrating diverse computational models with minimal computational time and cost, while polynomial chaos expansion and polynomial chaos Kriging exhibit greater capability in predicting propagated uncertainties within the computational models.