Neuronal plasma biomarkers in acute ischemic stroke
Early imaging-based detection of acute ischemic stroke (AIS) has improved in the era of reperfusion therapy. Despite of this, prognosis of outcome after AIS remains a challenge. Therefore, parameters that support clinical decision making are sought. Blood-based biomarkers have the potential to provide valuable information in addition to the established prognostic factors. Neuronal biomarkers of acute or degenerative neuronal injury have shown to be reliably detected in plasma. These biomarkers are well-established in neurodegenerative pathology, such as Alzheimer's disease. In this study, we explored the association between stroke diameter and plasma biomarkers for neuronal injury and tau pathophysiology (brain-derived tau [BD-tau], phosphorylated-tau-217 [p-tau21] and neurofilament light [NfL]) in patients (n = 193) admitted to the acute ward, Akershus University Hospital. All patients received a final diagnosis of AIS, transient ischemic attack or stroke mimics. Blood samples were obtained the day after admission. We find that levels of BD-tau (p = .004) and NfL (p = .011) were higher after AIS than in patients with stroke mimics. The cortical stroke diameter correlated with BD-tau (tau-b = 0.64, p < .001) and p-tau217 (tau-b = 0.36, p = .003). Linear regression confirmed BD-tau to be the strongest variable associated with stroke diameter, pointing to the potential clinical value of plasma BD-tau in outcome prediction after AIS.
Authors
- Berglind Gísladóttir (ORCID: https://orcid.org/0000-0002-1787-3006)
- Bjørn‐Eivind Kirsebom (ORCID: https://orcid.org/0000-0002-1413-9578)
- Hlin Kvartsberg (ORCID: https://orcid.org/0000-0002-4481-508X)
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Ole Morten Rønning (ORCID: https://orcid.org/0000-0001-5080-5788)
- Tormod Fladby (ORCID: https://orcid.org/0000-0002-9984-9797)
- Julia K. Gundersen (ORCID: https://orcid.org/0000-0001-8064-7266)
- Katrin Mertes
- Henrik Zetterberg
- Kaj Blennow
Institutions
- University of Wisconsin–Madison (US)
- University of Freiburg (DE)
- University of Pittsburgh (US)
- University of Oslo (NO)
- Akershus University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Cerebral Blood Flow & Metabolism
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1177/0271678x241293537
- Citations
- 11
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- BrightFocus Foundation
- Familjen Erling-Perssons Stiftelse
- Gun och Bertil Stohnes Stiftelse
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- University College London
- European Commission
- Vetenskapsrådet
- Alzheimerfonden
- International Society for Neurochemistry
- UK Dementia Research Institute
- Parkinsonfonden
- HORIZON EUROPE Framework Programme