Evolution of inflammatory markers in patients with prosthetic joint infection treated with Stimulan

STIMULAN (Abstract): Total hip arthroplasty is a commonly performed procedure with a known risk of postoperative infection.Diagnosing an infection after total hip arthroplasty can be challenging, as there are no consistently reliable preoperative tests for infection in patients requiring a revision arthroplasty.This study aimed to assess the common investigative methods for diagnosing infection at the site of a previous arthroplasty and the evolution of these biomarkers in patients treated with bioco mposite and traditional surgical treatment.Materials and methods: We conducted a prospective analysis of pre-and postoperative investigations used to diagnose infection in 44 patients admitted from January 2017 to September 2023 at the "Sf.Apostol Andrei" County Clinical Emergency Hospital of Galati.Results: Our study group included 31.81%women and 68.19% men.The most common symptoms experienced by patients were pain and functional incapacity of the lower limb.Only ESR and CRP were elevated in all patients at a dmission.Their values decreased postoperatively, and determinations at two and six weeks postoperatively showed normalization of ESR, while CRP remained slightly elevated.Conclusions: The biological modifications were generally typical when considering the preope ratory moment, with notable rapid improvement in inflammatory status within the first six weeks post-surgery.The novel approach that includes bio composites seems to have major clinical impact on the future management of prosthetic joint infections given the cure rate and the general evolution.