Genetic and clinical factors influencing CF-associated liver disease: the impact of SERPINA1 variants and CFTR genotypes in Romanian pediatric cystic fibrosis patients
This pioneering study in Romania underscores the complexity of hepatic disease in CF. While specific CFTR genotypes and SERPINA1 alleles were not significantly associated with hepatic complications, the findings emphasize the importance of early diagnosis and monitoring using fibrosis markers to identify children at risk for liver involvement.
Authors
- Mădălina Petran (ORCID: https://orcid.org/0000-0002-6721-9328)
- Daniel‐Corneliu Leucuta (ORCID: https://orcid.org/0000-0003-4218-8622)
- Gabriela Viorela Nițescu (ORCID: https://orcid.org/0000-0002-5492-0975)
- Dan L. Dumitraşcu (ORCID: https://orcid.org/0000-0001-5404-7662)
- Adina Chiş (ORCID: https://orcid.org/0000-0002-1651-0860)
- Romana Vulturar (ORCID: https://orcid.org/0000-0003-2476-9706)
- S. Mosescu
- Maria Iacobescu (ORCID: https://orcid.org/0000-0002-0659-8926)
- Elena-Simona Moiceanu
- Iustina Violeta Stan
Institutions
- Carol Davila University of Medicine and Pharmacy (RO)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Clinical Emergency Hospital Bucharest (RO)
- Institutul National pentru Sanatatea Mamei si Copilului "Alessandrescu-Rusescu" (RO)
Publication Details
- Journal
- Medicine and Pharmacy Reports
- Published
- 2024-10-24
- DOI
- https://doi.org/10.15386/mpr-2801
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitatea de Medicină şi Farmacie Iuliu Haţieganu Cluj-Napoca