Design, characterization and biocompatibility evaluation of polymeric networks as carriers for Indomethacin modified release

Pharmaceutical nanotechnology's progression expands drug versatility, utilizing carrier systems to efficiently deliver active ingredients to targeted tissues for controlled r elease within effective concentrations.Integrating nonsteroidal anti -inflammatory drugs (NSAIDs) into nano-systems holds potential for enhancing pharmacokinetic properties and diminishing adverse effects.Aim: Our study concentrated on formulating nanoparticles embedding indomethacin (IND), characterizing them, exploring drug release dynamics, and assessing their biocompatibility in rats.Materials and methods: IND was loaded within copolymeric networks comprising poly(2-hydroxyethyl methacrylate-co-3,9-divinyl-2,4,8,10tetraoxaspiro [5.5]-undecane) and poly(aspartic acid) (PAS) as a protective colloid, employing a dispersion polymerization approach.Fourier transform infrared spectroscopy (FT -IR) characterized the copolymeric matrices, and spectrophotometric analysis via dissolution method evaluated in vitro IND release.In vivo biocompatibility was gauged by monitoring hematological, biochemical, and immune parameters in rats.Results: Our developed nanosystems effectively loaded IND within polymeric matrices.The kinetics of IND release were influenced by copolymer composition, with lower comonomer concentrations extending release duration.The investigated copolymer networks incorporating IND did not elicit signi ficant hematological, biochemical, or immune changes when administered to rats.Conclusions: the studied polymer samples exhibited promising in vivo biocompatibility, positioning them as potential candidates for IND modified-release systems with prospective biomedical applications.