Clostridium spiroforme-induced diarrhea in a patient with acute myeloid leukemia: A case report

Clostridium spiroforme is a Gram-positive, obligate anaerobic bacillus. Previous studies have suggested that C. spiroforme mainly causes typhlocolitis and enterotoxemia in rabbits, with few documented cases of human infections. We present a rare case of acute diarrhea caused by C. spiroforme in a 78-year-old female patient with acute leukemia. In the early stages of infection, the patient experienced up to 10 episodes of diarrhea per day. She was subsequently treated with live Clostridium butyricum capsules to modulate the intestinal microflora, and her symptoms resolved after 7 days of treatment. This case report highlights an uncommon intestinal infection with C. spiroforme in a patient with a hematologic malignancy, contributing valuable clinical insights into this rare infection.