Splenectomy prevents brain orexin, ghrelin, or oxytocin but not GLP‐1‐induced improvement of intestinal barrier function in rats
The present results suggested that the spleen is important in the improvement of intestinal barrier function by brain orexin, ghrelin or oxytocin, and butyrate. On the other hand, GLP-1 acts centrally in the brain to improve colonic hyperpermeability in a spleen-independent manner. All these results suggest that dual mechanisms (spleen dependent or independent) may exist for the brain-gut regulation in intestinal barrier function.
Authors
- Masayo Yamamoto (ORCID: https://orcid.org/0000-0003-2001-199X)
- Tsukasa Nozu (ORCID: https://orcid.org/0000-0003-4225-2575)
- Hiroki Tanaka (ORCID: https://orcid.org/0000-0003-0011-3454)
- Shuichiro Takahashi (ORCID: https://orcid.org/0000-0002-3850-0559)
- Sho Igarashi
- Takeshi Saito (ORCID: https://orcid.org/0000-0002-6908-0702)
- Motohiro Shindo (ORCID: https://orcid.org/0000-0003-0754-9568)
- Toshikatsu Okumura (ORCID: https://orcid.org/0000-0003-1810-007X)
- Mayumi Hatayama
- Yasumichi Toki
- Takuya Funayama
- Masatomo Ishioh (ORCID: https://orcid.org/0000-0002-2925-0906)
- Chihiro Sumi
Institutions
- Asahikawa Medical University (JP)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1111/nmo.14949
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science