Piezo1‐Mediated Mechanotransduction Contributes to Disturbed Flow‐Induced Atherosclerotic Endothelial Inflammation
Our study highlights the key role of Piezo1 in atherosclerotic endothelial inflammation, proposing the Piezo1-Ca<sup>2+</sup>/CaM/CaMKII-FAK/Src-YAP axis as a previously unknown endothelial mechanotransduction pathway. Piezo1 is expected to become a potential therapeutic target for atherosclerosis and cardiovascular diseases.
Authors
- Shaohan Zhang (ORCID: https://orcid.org/0009-0008-2059-587X)
- Chunxiao Jie
- Chunyong Chen (ORCID: https://orcid.org/0000-0003-2157-3871)
- Chao Xiao (ORCID: https://orcid.org/0000-0003-1781-9680)
- Chao Qin (ORCID: https://orcid.org/0000-0002-9965-2142)
- Jing Lu (ORCID: https://orcid.org/0009-0007-2414-493X)
- Dong Sheng Cheng (ORCID: https://orcid.org/0000-0003-0678-9543)
- Yueh-Wen Lan (ORCID: https://orcid.org/0009-0003-4340-956X)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Qiqihar Medical University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1161/jaha.123.035558
- Citations
- 35
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 11.43