Structural Covariance Networks in the Fetal Brain Reveal Altered Neurodevelopment for Specific Subtypes of Congenital Heart Disease
Structural covariance networks offer a sensitive, data-driven approach to explore whole-brain structural changes without anatomical priors. We used them to stratify a heterogenous patient cohort with CHD, highlighting similarities and differences between diagnoses during fetal neurodevelopment. Although there was a clear effect of abnormal fetal hemodynamics on structural brain maturation, our results suggest that this alone does not explain all the variation in brain development between individuals with CHD.
Authors
- A. David Edwards (ORCID: https://orcid.org/0000-0003-4801-7066)
- Reza Razavi (ORCID: https://orcid.org/0000-0003-1065-3008)
- Kuberan Pushparajah (ORCID: https://orcid.org/0000-0003-1541-1155)
- Alexandra F. Bonthrone (ORCID: https://orcid.org/0000-0001-5487-5564)
- Siân Wilson (ORCID: https://orcid.org/0000-0003-4617-3583)
- Serena J. Counsell (ORCID: https://orcid.org/0000-0002-8033-5673)
- Alexia Egloff (ORCID: https://orcid.org/0000-0002-2005-8328)
- Johannes K. Steinweg (ORCID: https://orcid.org/0000-0002-3366-0932)
- Daniel Cromb (ORCID: https://orcid.org/0000-0002-9814-8841)
- Alena Uus (ORCID: https://orcid.org/0000-0001-5796-2145)
- Milou P.M. van Poppel (ORCID: https://orcid.org/0000-0002-1739-4726)
- David Lloyd (ORCID: https://orcid.org/0000-0003-1759-6106)
- Jonathan O’Muircheartaigh (ORCID: https://orcid.org/0000-0002-8033-6959)
- J.K. Simpson (ORCID: https://orcid.org/0000-0001-6546-0954)
- Anthony N. Price (ORCID: https://orcid.org/0000-0002-6907-7554)
- Mary Rutherford (ORCID: https://orcid.org/0000-0003-3361-1337)
- Joseph V. Hajnal (ORCID: https://orcid.org/0000-0002-2690-5495)
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- King's College London (GB)
- Evelina London Children's Healthcare (GB)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1161/jaha.124.035880
- Citations
- 7
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Wellcome Trust
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- National Institute for Health and Care Research
- King's College London
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Centre For Medical Engineering, King’s College London