Optimizing chemically stable chloramphenicol in-situ gel formulations using poloxamer 407 and HPMC through full-factorial design
The primary goal was to enhance the stability and bioavailability of chloramphenicol for ophthalmic use without compromising patient comfort, such as causing blurry vision. This study employed a 2-level full factorial design to optimize the formulation, exploring different concentrations of poloxamer 407 and HPMC to achieve this objective.
Authors
- Taofik Rusdiana (ORCID: https://orcid.org/0000-0002-3321-2179)
- Habibah A. Wahab (ORCID: https://orcid.org/0000-0002-8353-8679)
- Insi Farisa Desy Arya (ORCID: https://orcid.org/0000-0002-7240-2629)
- Handrian Ramoko
- Insan Sunan Kurniawansyah (ORCID: https://orcid.org/0000-0001-9093-789X)
Institutions
- Universiti Sains Malaysia (MY)
- Padjadjaran University (ID)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1038/s41598-024-74945-w
- Citations
- 5
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- Universitas Padjadjaran