High PD-1 and CTLA-4 expression correlates with host immune suppression in patients and a mouse model infected with Echinococcus multilocularis
E. multilocularis regulated the function of T cells via the PD-1/PD-L1- and CTLA-4-dependent pathways and subsequently evaded host immune attacks. These findings provide insights for investigating the pathogenic mechanism of AE.
Authors
- Shu Shen (ORCID: https://orcid.org/0000-0002-4737-171X)
- Yiwen Qiu (ORCID: https://orcid.org/0000-0003-0022-4824)
- Yi Yang (ORCID: https://orcid.org/0000-0002-6500-2635)
- Ting Sun (ORCID: https://orcid.org/0000-0001-8287-0541)
- Wentao Wang (ORCID: https://orcid.org/0000-0001-5190-3355)
- Min Yang (ORCID: https://orcid.org/0000-0002-9034-3175)
- Tao Wang (ORCID: https://orcid.org/0000-0003-4140-8734)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1186/s13071-024-06511-2
- Citations
- 5
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- National Natural Science Foundation of China
- Sichuan University
- West China Hospital, Sichuan University