Chemoenzymatic Synthesis of Phosphosaccharides from <i>Haemophilus parasuis</i> Strains ER-6P (Serovar 15) and Nagasaki (Serovar 5)
Herein, we describe a chemoenzymatic and diversity-oriented approach for the first syntheses of octasaccharide repeating units of the capsular polysaccharides of <i>Haemophilus parasuis</i> serovar 15 and serovar 5. The synthetic method features efficient enzymatic assembly of sialyl galactose or <i>N</i>-acetyl-galactosamine building blocks, highly stereoselective chemical construction of α-type <i>H</i>-phosphonate, and the β-stereospecific 1,3-glycosylation reaction of a rare sugar donor.
Authors
- Na Sun (ORCID: https://orcid.org/0000-0003-0155-1763)
- Hongzhi Cao (ORCID: https://orcid.org/0000-0003-4736-3143)
- Wenlong Yao (ORCID: https://orcid.org/0000-0002-9263-294X)
- Yugen Zhu (ORCID: https://orcid.org/0000-0002-7864-7045)
- Chang‐Cheng Liu (ORCID: https://orcid.org/0000-0002-5586-4776)
- Hui Xia (ORCID: https://orcid.org/0000-0001-7326-5796)
- Mei Chen (ORCID: https://orcid.org/0000-0003-2137-8304)
- Xinhao Zhu (ORCID: https://orcid.org/0000-0002-5553-163X)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shandong University (CN)
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Shanghai Institute of Materia Medica (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- State Key Laboratory of Natural and Biomimetic Drugs (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1021/acs.orglett.4c03665
- Citations
- 1
- Primary Topic
- Microbial infections and disease research
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- Shandong University
- Department of Science and Technology of Shandong Province
- National Natural Science Foundation of China
- Youth Innovation Promotion Association of the Chinese Academy of Sciences