Evaluation of the Choroid Plexus Epithelium Inflammation <scp>TLR4</scp>/<scp>NF</scp>‐<scp>κB</scp>/<scp>NKCC1</scp> Signal Pathway Activation in the Development of Hydrocephalus
These results confirmed that the inflammatory reaction contributes TLR4/NF-κB/NKCC1 mediated CPE abnormal secretion and consequent hydrocephalus. Regulation of TLR4/NF-κB/NKCC1 and AQP1 can prevent this process. Our study provides a strong rationale for further exploring alleviating CPE abnormal secretion as a therapeutic perspective of hydrocephalus.
Authors
- Jiawei He (ORCID: https://orcid.org/0000-0003-1636-1823)
- Xinfeng Liu (ORCID: https://orcid.org/0000-0002-8182-9632)
- Hao Xu (ORCID: https://orcid.org/0000-0002-8311-506X)
- Hua Du (ORCID: https://orcid.org/0000-0001-8669-4872)
- Xiaolei Jing
Institutions
- University of Science and Technology of China (CN)
- Hefei Institutes of Physical Science (CN)
- First Affiliated Hospital of Xiamen University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1111/cns.70085
- Citations
- 9
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- National Natural Science Foundation of China