Real‐world data on the efficacy and safety of hedgehog pathway inhibitors in patients with basal cell carcinoma: Experience of a tertiary Australian centre
In our cohort of 23 patients being treated with HPI, the ORR was 87% and CR was 39%. All patients who experienced TEAEs and had a drug holiday successfully responded to HPI rechallenge. TEAEs, particularly muscle spasms, are common reasons for treatment cessation. Clinicians should implement strategies to mitigate TEAE to improve drug survivability.
Authors
- Melissa Peera (ORCID: https://orcid.org/0000-0002-8931-9987)
- Marlene Wijaya (ORCID: https://orcid.org/0000-0002-3137-5847)
- María Jones‐Caballero (ORCID: https://orcid.org/0000-0002-5738-9921)
- Kelvin Truong (ORCID: https://orcid.org/0000-0002-9596-4499)
- Rose C Liu (ORCID: https://orcid.org/0000-0001-5564-8670)
- Pablo Fernández‐Peñas (ORCID: https://orcid.org/0000-0003-4882-1564)
- Raquel Ruiz Araujo (ORCID: https://orcid.org/0000-0003-0478-3754)
Institutions
- The University of Sydney (AU)
- Westmead Hospital (AU)
Publication Details
- Journal
- Australasian Journal of Dermatology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1111/ajd.14373
- Citations
- 2
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.47