Prognostic significance of adjuvant therapy and specific radiation dosages in Taiwanese patients with oral cavity cancer and extra-nodal extension: a nationwide cohort study
For OCSCC patients with ENE, our study shows CRT improved survivals than RT alone, underscoring the clinical significance of chemotherapy. Patients undergoing CRT with irradiation doses ranging from 6000 to 6500 cGy exhibited comparable survival outcomes to those receiving doses of 6600-7000 cGy. This observation suggests that irradiation doses exceeding the 6600 cGy may not confer the survival advantage in these patients. Further research is needed to confirm our results and explore the optimal irradiation dose for managing these patients.
Authors
- Ku‐Hao Fang (ORCID: https://orcid.org/0000-0002-1458-5041)
- Yu-Chien Wang
- Yu‐Wen Wen (ORCID: https://orcid.org/0000-0002-7979-3845)
- Chun‐Ta Liao (ORCID: https://orcid.org/0000-0002-3677-4249)
- Chung‐Kan Tsao (ORCID: https://orcid.org/0000-0003-3995-5894)
- Chih‐Hua Yeh (ORCID: https://orcid.org/0000-0001-6988-8739)
- Shu‐Ru Lee (ORCID: https://orcid.org/0000-0002-0459-3996)
- Tsung-Ming Chen (ORCID: https://orcid.org/0000-0002-5462-1668)
- Yao‐Te Tsai (ORCID: https://orcid.org/0000-0002-2313-0890)
- Shiang‐Fu Huang (ORCID: https://orcid.org/0000-0003-3582-9938)
- Hung‐Ming Wang (ORCID: https://orcid.org/0000-0002-2319-3285)
- Chun‐Hung Hua
- Chien-Yu Lin (ORCID: https://orcid.org/0000-0003-0118-3112)
- Tzu‐Chen Yen (ORCID: https://orcid.org/0000-0002-6136-0486)
- Jin‐Ching Lin (ORCID: https://orcid.org/0000-0003-2470-1242)
- Shyuang‐Der Terng (ORCID: https://orcid.org/0000-0002-6933-7176)
- Wan‐Ni Lin (ORCID: https://orcid.org/0000-0001-5782-8835)
- Li‐Yu Lee
- Shu‐Hang Ng (ORCID: https://orcid.org/0000-0002-1842-6179)
- Li‐Ang Lee (ORCID: https://orcid.org/0000-0001-8414-595X)
- Kang‐Hsing Fan (ORCID: https://orcid.org/0000-0002-0910-7803)
- Cheng‐Ping Wang (ORCID: https://orcid.org/0000-0001-7872-1463)
- Chih‐Yen Chien (ORCID: https://orcid.org/0000-0002-6690-6038)
- Chung‐Jan Kang (ORCID: https://orcid.org/0000-0002-5333-9396)
- Li‐Jen Hsin (ORCID: https://orcid.org/0000-0001-9201-0270)
- Tuan‐Jen Fang (ORCID: https://orcid.org/0000-0002-0164-3724)
- Wen‐Cheng Chen (ORCID: https://orcid.org/0000-0002-5581-9991)
- Chih‐Hung Lin
- Chia‐Hsun Hsieh
- Nai‐Ming Cheng
- Chi‐Ying Tsai
Institutions
- National Sun Yat-sen University (TW)
- Chang Gung University (TW)
- China Medical University (TW)
- Chang Gung Memorial Hospital (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
- China Medical University Hospital (TW)
- National Taiwan University Hospital (TW)
- Koo Foundation Sun Yat-Sen Cancer Center (TW)
- Chiayi Chang Gung Memorial Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Changhua Christian Hospital (TW)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1186/s12885-024-13048-1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chang Gung University
- Chang Gung Medical Foundation
- Chang Gung Memorial Hospital, Linkou