Combined analysis of a serum mRNA/miRNA marker signature and CA 19‐9 for timely and accurate diagnosis of recurrence after resection of pancreatic ductal adenocarcinoma: A prospective multicenter cohort study
TaqMan array card measurements were found to be biologically valid and technically reproducible. The BioPac multianalyte marker panel is capable of sensitive and accurate detection of recurrence in patients resected for PDAC using a simple blood test. This could allow a closer follow-up using shorter time intervals than currently used for imaging, thus potentially prompting an earlier work-up with additional modalities to allow for earlier therapeutic intervention. This study provides a promising approach for improved postoperative monitoring of resected PDAC patients, which is an urgent and unmet clinical need.
Authors
- Thilo Hackert (ORCID: https://orcid.org/0000-0002-7012-1196)
- Aldo Scarpa
- Hans Armin Kestler (ORCID: https://orcid.org/0000-0002-4759-5254)
- Ludwig Lausser
- Miriam Schenk (ORCID: https://orcid.org/0000-0003-0208-7958)
- Markus Wolfgang Büchler (ORCID: https://orcid.org/0000-0002-3666-5675)
- Núria Malats (ORCID: https://orcid.org/0000-0003-2538-3784)
- Nathalia A. Giese (ORCID: https://orcid.org/0000-0001-5920-3142)
- Rita T. Lawlor (ORCID: https://orcid.org/0000-0003-3160-0634)
- Malte Buchholz (ORCID: https://orcid.org/0000-0002-2833-995X)
- Christine Tjaden
- Julie Earl (ORCID: https://orcid.org/0000-0001-9360-4716)
- Alfredo Carrato (ORCID: https://orcid.org/0000-0001-7749-8140)
- Alfonso Sanjuánbenito
- Thomas M. Gress (ORCID: https://orcid.org/0000-0002-9333-5461)
Institutions
- University of Verona (IT)
- Philipps University of Marburg (DE)
- Universität Ulm (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Spanish National Cancer Research Centre (ES)
- Technische Hochschule Ingolstadt (DE)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Chirurgische Universitätsklinik Heidelberg (DE)
Publication Details
- Journal
- United European Gastroenterology Journal
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1002/ueg2.12676
- Citations
- 3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Instituto de Salud Carlos III