Surgical Resection Followed by Stereotactic Radiosurgery (S+SRS) Versus SRS Alone for Large Posterior Fossa Brain Metastases: A Comparative Analysis of Outcomes and Factors Guiding Treatment Modality Selection
A higher proportion of patients treated with S+SRS presented with hydrocephalus, fourth-ventricle compression, and larger lesion volumes. SRS-alone patients had a lower KPS, a lower GPA, and more brain metastases. S+SRS correlated with improved OS, suggesting that it should be seriously considered for patients with large PF-BrM.
Authors
- Ruth Lau (ORCID: https://orcid.org/0000-0002-8640-2339)
- Mark Bernstein (ORCID: https://orcid.org/0000-0001-8861-5664)
- Carolyn Lai (ORCID: https://orcid.org/0000-0002-8025-4195)
- Gelareh Zadeh (ORCID: https://orcid.org/0009-0009-2002-5313)
- Anna Santiago (ORCID: https://orcid.org/0000-0002-0932-2386)
- David Shultz (ORCID: https://orcid.org/0000-0001-8242-6555)
- Aristotelis Kalyvas (ORCID: https://orcid.org/0000-0002-0222-488X)
- Normand Laperrière (ORCID: https://orcid.org/0000-0001-8930-9650)
- Paul N. Kongkham (ORCID: https://orcid.org/0000-0002-1047-9305)
- Enrique Gutiérrez (ORCID: https://orcid.org/0000-0002-3524-2339)
- Danyal Ahmed (ORCID: https://orcid.org/0000-0002-6903-0182)
- Parnian Habibi
- Tatiana Conrad
- Barbara‐Ann Millar
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Princess Margaret Cancer Centre (CA)
Publication Details
- Journal
- Brain Sciences
- Published
- 2024-10-25
- DOI
- https://doi.org/10.3390/brainsci14111059
- Citations
- 3
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.26