B and T Cell Bi-Cistronic Multiepitopic Vaccine Induces Broad Immunogenicity and Provides Protection Against SARS-CoV-2
These findings underscore the potential of these multiepitopic proteins when expressed from DNA or MVA vectors to provide protection against SARS-CoV-2 and its variants, supporting their further development as next-generation COVID-19 vaccines.
Authors
- Carlos Óscar S. Sorzano (ORCID: https://orcid.org/0000-0002-9473-283X)
- María López‐Bravo (ORCID: https://orcid.org/0000-0002-1898-9465)
- Carmen Gómez (ORCID: https://orcid.org/0000-0002-5414-7935)
- Mariano Estéban (ORCID: https://orcid.org/0000-0003-0846-2827)
- José Ramón Valverde (ORCID: https://orcid.org/0000-0002-6655-7114)
- Susana Guerra (ORCID: https://orcid.org/0000-0001-9067-2991)
- Laura Sin (ORCID: https://orcid.org/0000-0001-6115-5610)
- Michela Falqui (ORCID: https://orcid.org/0000-0003-3636-8686)
- Rocío Coloma (ORCID: https://orcid.org/0000-0003-0365-1565)
- Beatriz Perdiguero (ORCID: https://orcid.org/0000-0001-6276-7766)
- Enrique Álvarez (ORCID: https://orcid.org/0000-0001-8308-7524)
- Laura Marcos-Villar (ORCID: https://orcid.org/0000-0002-8635-6432)
Institutions
- Consejo Superior de Investigaciones Científicas (ES)
- Instituto de Salud Carlos III (ES)
- Centro Nacional de Biotecnología (ES)
- Centro de Investigación Biomédica en Red (ES)
- Universidad Autónoma de Madrid (ES)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Vaccines
- Published
- 2024-10-25
- DOI
- https://doi.org/10.3390/vaccines12111213
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
- Comunidad de Madrid
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III
- Centro Nacional de Biotecnología