Effect of RTS,S/AS01E vaccine booster dose on cellular immune responses in African infants and children

RTS,S/AS01<sub>E</sub>, the first approved malaria vaccine, demonstrated moderate efficacy during the phase 3 pediatric trial. We previously investigated cell-mediated immune (CMI) responses following the primary 3-dose immunization and now report responses to the booster dose given 18 months later. Thirty CMI markers were measured by Luminex in supernatants of peripheral blood mononuclear cells from 709 children and infants after RTS,S/AS01<sub>E</sub> antigen stimulation, and their associations with malaria risk and antibodies one month post-booster and one year later were assessed. IL-2, IFN-γ, IL-17, IL-5, and IL-13 were associated with RTS,S/AS01<sub>E</sub> booster vaccination, and IL-2 responses to the circumsporozoite protein (CSP) remained higher after one year. IL-2 was associated with reduced malaria risk in one site, and IL-10 was associated with increased risk in infants. Anti-CSP IgG and IL-2 were moderately correlated one year after booster. This study highlights the moderate cell-mediated immunogenicity of the RTS,S/AS01<sub>E</sub> booster dose that aligns with partial recovery of RTS,S/AS01<sub>E</sub> vaccine efficacy.

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Publication Details

Journal
npj Vaccines
Published
2024-10-25
DOI
https://doi.org/10.1038/s41541-024-00977-y
Citations
2
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.78

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article

Effect of RTS,S/AS01E vaccine booster dose on cellular immune responses in African infants and children

Ana Chopo-Pizarro, Robert A. Mitchell, Gemma Moncunill, Maxmillian Mpina et al.
2 citations
npj Vaccines
SARS-CoV-2 and COVID-19 Research
0.78
article

Effect of RTS,S/AS01E vaccine booster dose on cellular immune responses in African infants and children

Ana Chopo-Pizarro, Robert A. Mitchell, Gemma Moncunill, Maxmillian Mpina, Miquel Vázquez-Santiago, Chenjerai Jairoce, Dídac Macià, Ruth Aguilar, Akshayata Naidu, Joseph J. Campo, Claudia Daubenberger, Pedro Aíde, Carlota Dobaño
article en
2 citations

Abstract

RTS,S/AS01<sub>E</sub>, the first approved malaria vaccine, demonstrated moderate efficacy during the phase 3 pediatric trial. We previously investigated cell-mediated immune (CMI) responses following the primary 3-dose immunization and now report responses to the booster dose given 18 months later. Thirty CMI markers were measured by Luminex in supernatants of peripheral blood mononuclear cells from 709 children and infants after RTS,S/AS01<sub>E</sub> antigen stimulation, and their associations with malaria risk and antibodies one month post-booster and one year later were assessed. IL-2, IFN-γ, IL-17, IL-5, and IL-13 were associated with RTS,S/AS01<sub>E</sub> booster vaccination, and IL-2 responses to the circumsporozoite protein (CSP) remained higher after one year. IL-2 was associated with reduced malaria risk in one site, and IL-10 was associated with increased risk in infants. Anti-CSP IgG and IL-2 were moderately correlated one year after booster. This study highlights the moderate cell-mediated immunogenicity of the RTS,S/AS01<sub>E</sub> booster dose that aligns with partial recovery of RTS,S/AS01<sub>E</sub> vaccine efficacy.

npj VaccinesVol. 9(1)
Ifakara Health Institute (TZ), Swiss Tropical and Public Health Institute (CH), University of Basel (CH), Centro de Investigación en Red en Enfermedades Cardiovasculares (ES), Departament de Salut (ES), Manhiça Health Research Centre (MZ), Barcelona Institute for Global Health (ES), Universitat de Barcelona (ES)
Bill and Melinda Gates Foundation, GlaxoSmithKline
Zero hunger
Openalex Percentile: Top 27%
SARS-CoV-2 and COVID-19 Research
0.78
DOIOpen Access PDFOpenAlex
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