Unveiling the causal effects of gut microbiome on trimethylamine N-oxide: evidence from Mendelian randomization
Our findings revealed the role of the <i>phylum Pseudomonadota, family Sutterellaceae, species Bacteroides finegoldii</i>, and <i>Bacteroides uniformis</i> in increasing TMAO, as well as the <i>species Bacteroides thetaiotaomicron</i> and <i>Bilophila wadsworthia</i> in decreasing TMAO. This study provides new insights into the relationship between the gut microbiome and TMAO levels.
Authors
- Juan Deng (ORCID: https://orcid.org/0009-0007-5963-0583)
- Xinyu Yang (ORCID: https://orcid.org/0000-0001-5117-4914)
- Yunfeng Yu (ORCID: https://orcid.org/0000-0002-0992-4694)
- Yuman Yin
- Rong Yu (ORCID: https://orcid.org/0000-0001-6861-8737)
- Siyang Bai
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-10-25
- DOI
- https://doi.org/10.3389/fmicb.2024.1465455
- Citations
- 9
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Natural Science Foundation of China
- Hunan University
- Hunan University of Chinese Medicine