New Discorhabdin D Analogues from <i>Latrunculia</i> spp. Sponges
Chemical profiles of <i>Latrunculia kaakaariki</i> and <i>Latrunculia brevis</i> were investigated, resulting in the isolation of five new discorhabdin D derivatives <b>1</b> and <b>3</b>-<b>6</b>. Their planar structures were solved by combination of NMR and HR-MS, while <i>J</i>-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds <b>5</b> and <b>6</b> showed low micromolar potency.
Authors
- William D. Figg (ORCID: https://orcid.org/0000-0002-5875-2606)
- Maria Orfanoudaki (ORCID: https://orcid.org/0000-0002-9409-7645)
- Masoumeh Dalilian
- Tanja Grkovic (ORCID: https://orcid.org/0000-0002-6537-3997)
- Barry R. O’Keefe (ORCID: https://orcid.org/0000-0003-0772-4856)
- Lin Du (ORCID: https://orcid.org/0000-0001-8751-4482)
- Cindy H. Chau (ORCID: https://orcid.org/0000-0002-6928-3833)
Institutions
- National Institutes of Health (US)
- Target (United States) (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1021/acs.jnatprod.4c01036
- Citations
- 2
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Cancer Institute