A Translational Study of the ATR Inhibitor Berzosertib as Monotherapy in Four Molecularly Defined Cohorts of Advanced Solid Tumors
Across cohorts, only patients with SDH-mutant GIST experienced prolonged disease control. Despite evidence of target engagement, patients enrolled to all other cohorts had short PFS, suggesting rapid adaptation to ATR inhibitor monotherapy. Among these patients, those with tumors expressing SLFN11 during berzosertib exposure derived the most clinical benefit.
Authors
- Oladapo Yeku (ORCID: https://orcid.org/0000-0002-6319-1647)
- Alona Muzikansky (ORCID: https://orcid.org/0000-0001-7585-8181)
- James M. Cleary (ORCID: https://orcid.org/0000-0001-7213-3951)
- Colin D. Weekes (ORCID: https://orcid.org/0000-0001-6287-4334)
- Lee Zou (ORCID: https://orcid.org/0000-0003-3094-1058)
- Aparna R. Parikh (ORCID: https://orcid.org/0000-0002-5245-7841)
- Geoffrey Ira Shapiro (ORCID: https://orcid.org/0000-0002-3331-4095)
- Daniel E. McLoughlin (ORCID: https://orcid.org/0000-0002-3697-9623)
- Jong Chul Park (ORCID: https://orcid.org/0000-0002-1052-0734)
- Andrea J. Bullock (ORCID: https://orcid.org/0000-0001-7143-0225)
- T. Khanh (ORCID: https://orcid.org/0000-0002-9411-8899)
- Bose Kochupurakkal (ORCID: https://orcid.org/0000-0001-8929-3070)
- Xin Gao (ORCID: https://orcid.org/0009-0008-2346-068X)
- Gregory M. Coté (ORCID: https://orcid.org/0000-0003-0181-886X)
- Michael L. Cheng (ORCID: https://orcid.org/0000-0002-7409-288X)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Duke University (US)
- University of California, San Francisco (US)
- Massachusetts General Hospital (US)
- Dana-Farber Cancer Institute (US)
- Center for Cancer Research (US)
- Duke University Hospital (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1867
- Citations
- 7
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Mass General Cancer Center