Impact of low dose inhaled nitric oxide treatment in spontaneously breathing and intubated COVID-19 patients: a retrospective propensity-matched study
This retrospective propensity-score matched study showed that spontaneously breathing COVID-19 patients on HFNC/ NIV support had a decreased in-hospital mortality risk with iNO use in a time-to-event analysis. Both intubated and spontaneously breathing patients had improvement in oxygenation parameters with iNO therapy but were associated with longer in-hospital stays, ICU stays, ventilation duration, and higher incidence of creatinine rise.
Authors
- Arvind Balavenkataraman (ORCID: https://orcid.org/0000-0002-0096-4294)
- Sean M. Caples
- Abby Hanson (ORCID: https://orcid.org/0000-0003-3195-511X)
- Quintin J. Quiñones
- Swetha Reddy (ORCID: https://orcid.org/0000-0002-7640-5771)
- Anirban Bhattacharyya (ORCID: https://orcid.org/0000-0003-1077-2082)
- Vikas Bansal (ORCID: https://orcid.org/0000-0002-6684-5335)
- Devang K. Sanghavi (ORCID: https://orcid.org/0000-0003-4742-8963)
- Anna Jenkins (ORCID: https://orcid.org/0000-0003-3498-8312)
- Subekshya Khadka
- Abigail T. LaNou
- Syed Anjum Khan (ORCID: https://orcid.org/0000-0002-2452-2079)
- Sadhana Jonna (ORCID: https://orcid.org/0000-0002-6380-7616)
- Neal M. Patel (ORCID: https://orcid.org/0000-0001-5242-2385)
- JORGE SINCLAIR DE FRÍAS (ORCID: https://orcid.org/0000-0002-7556-8851)
- Carla Venegas
- Ananya Vasudhar
- Ricardo Diaz Milian (ORCID: https://orcid.org/0000-0003-1253-0343)
- Prasanth Balasubramanian (ORCID: https://orcid.org/0000-0002-8963-1583)
- Sean Kiley (ORCID: https://orcid.org/0000-0001-5930-4795)
- Pablo Moreno Franco (ORCID: https://orcid.org/0000-0001-9146-5599)
- Sanjay Chaudhary (ORCID: https://orcid.org/0000-0003-4127-5572)
- Lekhya Raavi
- Aysun Tekin
- Nitesh Jain (ORCID: https://orcid.org/0000-0003-0139-3515)
- Rahul Kashyap (ORCID: https://orcid.org/0000-0002-4383-3411)
- Shahin Isha (ORCID: https://orcid.org/0000-0002-6613-6395)
- Pramod Kumar Guru (ORCID: https://orcid.org/0000-0001-7695-4407)
- Rodrigo Cartin‐Ceba (ORCID: https://orcid.org/0000-0001-6738-9821)
- Anna B Shapiro
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- Mayo Clinic Health System (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Critical Care
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1186/s13054-024-05093-w
- Citations
- 9
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.77