Postoperative Innate Immune Dysregulation, Proteomic, and Monocyte Epigenomic Changes After Colorectal Surgery: A Substudy of a Randomized Controlled Trial
These findings illuminate the complex epigenetic modulation influencing monocytes' response to surgical stress, shedding light on potential biomarkers for immune dysregulation. Our results advocate for further research into the role of anesthesia in these molecular pathways and the development of personalized interventions to mitigate immune dysfunction after surgery.
Authors
- Fatih Polat (ORCID: https://orcid.org/0000-0002-8758-8040)
- Christiaan Keijzer (ORCID: https://orcid.org/0000-0002-0428-9687)
- Mihai Gheorghe Netea (ORCID: https://orcid.org/0000-0003-2421-6052)
- Kim I. Albers (ORCID: https://orcid.org/0000-0002-9770-0905)
- Leo A. B. Joosten (ORCID: https://orcid.org/0000-0001-6166-9830)
- Marc Snoeck
- Musa M. Mhlanga (ORCID: https://orcid.org/0000-0003-1381-3409)
- Lucas van Eijk
- Matthijs Kox (ORCID: https://orcid.org/0000-0001-6537-6971)
- Leonie S. Helder
- Y. Negishi (ORCID: https://orcid.org/0000-0002-5134-3957)
- Michiel C. Warlé (ORCID: https://orcid.org/0000-0002-1151-4571)
- Laszlo Groh (ORCID: https://orcid.org/0000-0001-7700-960X)
- Ivo F. Panhuizen
- Gert-Jan Scheffer
Institutions
- University of Bonn (DE)
- Radboud University Nijmegen (NL)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Radboud University Medical Center (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1213/ane.0000000000007297
- Citations
- 3
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.72