Expression of PD-L1, PD-L2, and inflammatory gene expression profile in locally advanced head and neck squamous cell carcinoma
High Tcell<sub>inf</sub>GEP status, but not PD-L1 or PD-L2 expression, was independently associated with longer survival in patients with LA HNSCC. Results may have implications for evaluating therapies targeting programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) in HNSCC.
Authors
- Thanh‐Trung Vo (ORCID: https://orcid.org/0000-0003-0259-7165)
- Min Hee Hong (ORCID: https://orcid.org/0000-0003-3490-2195)
- Sun Och Yoon (ORCID: https://orcid.org/0000-0002-5115-1402)
- Andrea L. Webber (ORCID: https://orcid.org/0000-0003-2463-0878)
- Huaqiang Zhou (ORCID: https://orcid.org/0000-0003-3538-4481)
- Byoung Chul Cho (ORCID: https://orcid.org/0000-0002-5562-270X)
- Se‐Hoon Lee (ORCID: https://orcid.org/0000-0002-9219-3350)
- Yoon Woo Koh (ORCID: https://orcid.org/0000-0002-9734-1682)
- D. Chirovsky
- Sung‐Hwan Kim (ORCID: https://orcid.org/0000-0001-5743-6241)
- Jae‐Keun Cho (ORCID: https://orcid.org/0000-0001-7672-9007)
- M.-J. Ahn (ORCID: https://orcid.org/0009-0001-0519-9923)
- Hoiyun Jung
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Yonsei University (KR)
- Severance Hospital (KR)
- Samsung Medical Center (KR)
- Gangnam Severance Hospital (KR)
- Yonsei University Health System (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- ESMO Open
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1016/j.esmoop.2024.103961
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85