Polygenic risk, aspirin, and primary prevention of coronary artery disease
The balance between net benefit and harm on aspirin in the primary prevention setting shifts favourably in individuals with an elevated genetic predisposition.
Authors
- Paul Lacaze (ORCID: https://orcid.org/0000-0002-0902-6798)
- Franz‐Josef Neumann (ORCID: https://orcid.org/0000-0002-9478-2757)
- Amit Khera (ORCID: https://orcid.org/0000-0001-7255-6874)
- Chenglong Yu (ORCID: https://orcid.org/0000-0002-0546-2779)
- Sophia Zoungas (ORCID: https://orcid.org/0000-0003-2672-0949)
- Pradeep Natarajan (ORCID: https://orcid.org/0000-0001-8402-7435)
- Stephen James Nicholls (ORCID: https://orcid.org/0000-0002-9668-4368)
- John J. McNeil (ORCID: https://orcid.org/0000-0002-1049-5129)
- Christopher M. Reid (ORCID: https://orcid.org/0000-0001-9173-3944)
- Rory Wolfe (ORCID: https://orcid.org/0000-0002-2126-1045)
- Aniruddh P. Patel (ORCID: https://orcid.org/0000-0001-7871-9638)
- Harpreet Singh Bhatia (ORCID: https://orcid.org/0000-0002-3964-2989)
- Sotirios Tsimikas (ORCID: https://orcid.org/0000-0001-9834-9494)
- Andrew Tonkin
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- Verve Therapeutics (United States) (US)
- German Centre for Cardiovascular Research (DE)
- Australian Association of Gerontology (AU)
- Monash University (AU)
Publication Details
- Journal
- European Heart Journal - Cardiovascular Pharmacotherapy
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1093/ehjcvp/pvae085
- Citations
- 7
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Commonwealth Scientific and Industrial Research Organisation
- Monash University
- Menzies Institute for Medical Research
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Cancer Institute